Crudden Research Lab




M.W.A. MacLean, T.K. Wood, G. Wu, R.P. Lemieux, C.M. Crudden, “Chiral Periodic Mesoporous Organosilicas: Probing Chiral Induction in the Solid State”, Chem. Mater., 2014, 26 (20), 5852–5859.

E.C. Keske, B.D. Moore, O.V. Zenkina, R. Wang, G. Schatte and C.M. Crudden*, “Highly Selective Directed Arylation Reactions via Back-to-Back Dehydrogenative C-H Borylation/Arylation Reactions”, Chemical Communications, 2014, 9883-9886. 

S.C. Mathew,B.W. Glasspoole, P. Eisenberger, C.M. Crudden* “Synthesis of enantiomerically enriched triarylmethanes by enantiospecific Suzuki-Miyaura cross coupling reactions”, Journal of the American Chemical Society, 2014, 136 (16), 5828-5831. 

C.M. Crudden, J.H. Horton, I.I. Ebralidze, O.V. Zenkina, E.C. Keske, J.D. Leake, A. Rousina-Webb, A.B. McLean, B. Drevniok, T. Seki, G. Wu, N.J. Mosey, “Ultra Stable Self-Assembled Monolayers of N-Heterocyclic Carbenes on Gold.” Nature Chemistry, 2014, 6, 409-414 *Highlighted in Chemistry World (UK), Physics Today, Chemical & Engineering News (US), Canadian Chemical News and Science Media Centre Canada.

M. Nambo, C.M. Crudden, “Modular Synthesis of Triarylmethanes through Palladium-Catalyzed Sequential Arylation of Methyl Phenyl Sulfone.” Angewandte Chemie International Edition2014,742-746. *Highlighted in Synfacts  


L. Baptista de Oliveira Freitas, P. Eisenberger and C.M. Crudden, “Mesoionic carbene boranes.” Organometallics, 2013, 32 (22), 6635-6638.

L. Chausset-Boissarie, K. Ghozati, E. LaBine, J. L.-Y. Chen, V.K. Aggarwal and C.M. Crudden, “Enantiospecific, regioselective cross-coupling reactions of secondary allylic boronic esters.” Chemistry a European Journal, 2013, 19, 17698-17701.

B.W. Glasspoole, M.S. Oderinde,  B.D. Moore, A. Antoft-Finch and C. Crudden, “Highly Chemoselective and Enantiospecific Suzuki-Miyaura Cross Couplings of Benzylic Organoboronic Esters” Synthesis, 2013, 45(13), 1759-1763.

E.C. Keske, O.V. Zenkina, A. Asadi, H. Sun, J.M. Praetorius, D.P. Allen, D. Covelli, B.O. Patrick, R. Wang, P. Kennepohl, B.R. James and C.M. Crudden “Dioxygen Adducts of Rhodium N-Heterocyclic Carbene Complexes.” Dalton Transactions, 2013, 42, 7414-7423. 

O.V. Zenkina, E.C. Keske, G.S. Kochhar, R. Wang, and C.M. Crudden, “Heteroleptic NHC Rhodium Complexes with Pyridine-Derived Ligands: Synthetic Accessibility and Reactivity Towards Oxygen.” Dalton Transactions, 2013, 42, 2282-2293. 


P. Eisenberger, A.M. Bailey, C.M. Crudden, “Taking the F out of FLP. Simple Lewis acid-base pairs for mild reductions with neutral boranes via borenium ion catalysis.” Journal of the American Chemical Society, 2012, 134, 17384–17387. Highlighted in C&E News

J. Cipot-Wechsler, D. Covelli, J.M. Praetorius, O.V. Zenkina, E.C. Keske, N. Hearns, P. Kennepohl, C.M. Crudden, “Synthesis and Characterization of Cationic Rhodium Peroxo Complexes” Organometallics2012, 31, 7306-7315. Invited Cover Article

X. Wu, C.M. Crudden, “Chiral Hybrid Mesoporous Silicas: Assembly of Uniform Hollow Nanospheres and Helical Nanotubes with Tunable Diameters”, Chemistry of Materials, 2012, 24, 3839–3846 

E.C. Keske, O.V. Zenkina, R. Wang, C.M. Crudden, “Synthesis and Structure of Pd-1,2,3 Triazol-5-ylidene Mesoionic Carbene PEPPSI Complexes and Their Catalytic Applications in the Mizoroki-Heck Reaction”, Organometallics, 2012, 31, 6215–6221.

V. Jayalakshmi, T. Wood, R. Basu, J. Du, T. Blackburn, C. Rosenblatt, C.M. Crudden and R.P. Lemieux, “Probing the Pore Structure of a Chiral Periodic Mesoporous Organosilica Using Liquid Crystals”, Journal of Materials Chemistry, 2012, 22, 15255-15261

T. Seki, K. McEleney, C.M. Crudden “Enantioselective catalysis with a chiral, phosphane-containing PMO material​” Chemical Communications, 2012, 48, 6369-6371.

I. Ebralidze, M. Hanif, R. Arjumand, A. Azmi, D. Dixon, N. Cann, C.M. Crudden, Horton, J Hugh “Solvent induced adhesion interactions between dichlorotriazine films” Journal of Physical Chemistry C, 2012, 116, 4217-4223. 

B. W. Glasspoole, K. Ghozati, J. Moir, C.M. Crudden, “Suzuki-Miyaura Cross Couplings of Secondary Allylic Boronic Esters”, Chemical Communications, 2012, 48, 1230-1232.

E.C. Keske, O. V. Zenkina, R. Wang, C. Crudden, “Synthesis and Structure of Silver and Rhodium 1,2,3 Triazol-5-ylidene Mesoionic Carbene Complexes” Organometallics, 2012, 31, 456-461. 


  1. B.W. Glasspoole, C.M. Crudden “Cross-Coupling, the Final Frontier” Nature Chemistry, News and Views (Invited), 2011, 3, 912-913.

O.V. Zenkina, E. C. Keske, R. Wang, C.M. Crudden, “Dimeric Rhodium-ethylene NHC complexes as Reactive Intermediates for the Preparation of Tetra-heteroleptic NHC Complexes” Organometallics, 2011, 30, 6423-6432

O.V. Zenkina, E.C. Keske, R. Wang, C.M. Crudden, “Double Single-Crystal to Single-Crystal Transformations and Small Molecule Activation in Rhodium NHC Complexes” Angewandte Chemie International Edition, 2011, 35, 8100-8104. 

X. Wu, T. Blackburn, J. D. Webb, A. E. Garcia-Bennett, C.M. Crudden, “The Synthesis of Chiral Periodic Organosilica Materials with Ultrasmall Mesopores”, Angewandte Chemie International Edition, 2011, 35, 8095-8099. 

A. El Kadib, K. McEleney, T. Seki, T. K. Wood, C.M. Crudden, “Cross-Coupling in the Preparation of Pharmaceutically Relevant Substrates using Palladium Supported on Functionalized Mesoporous Silicas”, ChemCatChem, 2011, 3, 1281-1285.

S. El Hankari, A. El Kadib, A. Finiels, A. Bouhaouss, J.J.E. Moreau, C.M. Crudden, D. Brunel, P. Hesemann, “SBA-15-type Organosilica Bearing 4-mercapto-N,N-bis-(3-Si-Propyl)butanamide for Palladium Scavenging and Cross-Coupling Catalysis” Chemistry a European Journal, 2011, 17, 8984-8994.


J. Du, J. Cipot-Wechsler, J. Barnes, J. Lobez, H.P. Loock, C.M. Crudden, “Mesoporous Organosilica Films: Key Components of Fiber‐Optic‐Based Heavy‐Metal Sensors” Small, 2010, 6, 1168-1172.

J. D. Webb, V. Laberge, S. Geier, D. Stephan, C.M. Crudden “Borohydrides from Organic Hydrides: Reactions of Hantzsch’s Esters with B(C6F5)3” Chemistry a European Journal, 2010, 16, 4895-4902.

S.E. Dickson, C.M. Crudden “Transformable periodic mesoporous organosilica materials”, Chemical Communications, 2010, 46, 2100-2102.

J.M. Praetorius, R. Wang, C.M. Crudden “Benzimidazoles as Ligands in the Ruthenium-Catalyzed Enantioselective Bifunctional Hydrogenation of Ketones” Organometallics, 2010, 29, 554-561.

C.J. Lata, C.M. Crudden, “Dramatic effect of Lewis acids on the Rhodium-catalyzed hydroboration of Olefins” Journal of the American Chemical Society, 2010, 132, 131-137.

S. MacQuarrie, B. Nohair, J.H. Horton, S. Kaliaguine, C.M. Crudden “Functionalized Mesostructured Silicas as Supports for Palladium Catalysts: Effect of Pore Structure and Collapse on Catalytic Activity in the Suzuki-Miyaura Reaction”. Journal of Physical Chemistry C, 2010, 114, 57-64.